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標題Title: INCREASED EXPRESSION OF PROTEIN KINASE CK2Β SUBUNIT IN HUMAN GASTRIC CARCINOMA
作者Authors: 溫義輝,Kai-Yuan..等
上傳單位Department: 生物科技系
上傳時間Date: 2009-11-20
上傳者Author: 溫義輝
審核單位Department: 生物科技系
審核老師Teacher: 溫義輝
檔案類型Categories: 研討會報告Seminar Report
關鍵詞Keyword: CK2B, gastric carcinoma
摘要Abstract: Purposes: Gastric carcinoma is one of the most common malignancies in the world, and yet little is known about its molecular process of development and progression. The aims of this study were to correlate the expression of protein kinase CK2β subunit with clinicopathologic parameters and patients’ survival.

Materials and methods: CK2β protein levels were analyzed in tumor/non-tumor pairs of gastric tissues from surgical specimens of 79 patients with gastric carcinoma employing immunohistochemistry.

Results: CK2β protein expression was significantly upregulated in a retrospective cohort of 81 gastric carcinomas (P < 0.0001). Expression of CK2β was observed not only in cancer cells but also in precancerous lesion such as metaplastic and adenomatous cells. Overexpression of CK2β was correlated with histological type (P = 0.0007), degree of differentiation (P = 0.0005), nodal status (P = 0.0122), and TNM staging (P = 0.0197). There was no correlation between CK2β overexpression and overall survival (P = 0.061).

Conclusion: This study indicates that CK2β overexpression may contribute to the early event of gastric carcinoma development, ant it further suggests that selective inhibition may provide a chemopreventive effect against gastric carcinogenesis.

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