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標題Title: 蛋白質磷酸激酶CK2 β次單元與臨床病理因子之相關性以及作為胃癌預後指標之研究
作者Authors: 溫義輝,林凱元..等
上傳單位Department: 生物科技系
上傳時間Date: 2009-11-20
上傳者Author: 溫義輝
審核單位Department: 生物科技系
審核老師Teacher: 溫義輝
檔案類型Categories: 論文Thesis
關鍵詞Keyword: 蛋白質磷酸激酶CK2 β次單元, 胃癌, 預後
摘要Abstract: Purpose: Gastric carcinoma is one of the most common malignancies in the world, and yet little is known about its molecular process of development and progression. The aims of this study were to correlate the expression of protein kinase CK2β subunit with clinicopathologic parameters and patients’ survival.
Materials and Methods: Nuclear CK2β protein levels were analyzed in tumor/non-tumor pairs of gastric tissues from surgical specimens of 104 patients with gastric carcinoma employing immunohistochemistry.
Results: Overexpression of nuclear CK2β was significantly correlated with depth of invasion (P = 0.042). Patients with high expression levels of nuclear CK2β had a significantly poorer overall survival rate compared with patients with low expression levels of nuclear CK2β (P = 0.0006). In multi-variate Cox regression analysis, overexpression of nuclear CK2β and stage were proven to be independent prognostic markers for gastric carcinoma (P = 0.0036 and 0.0005, respectively).
Conclusion: This study indicates that CK2β overexpression can be used as an independent prognostic markers for gastric carcinoma.

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