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標題Title: Responsiveness and minimal clinically important differences after cholecystectomy: GIQLI versus SF-36
作者Authors: 溫義輝,Shi HY..等
上傳單位Department: 生物科技系
上傳時間Date: 2009-11-20
上傳者Author: 溫義輝
審核單位Department: 生物科技系
審核老師Teacher: 溫義輝
檔案類型Categories: 論文Thesis
關鍵詞Keyword: Responsiveness . Minimal clinically important differences . GIQLI . SF-36
摘要Abstract: Introduction To compare responsiveness and minimal clinically important differences (MCID) between the Gastrointestinal
Quality of Life (GIQLI) and the Short Form 36 (SF-36), we prospectively analyze 159 patients undergoing cholecystectomy
at two tertiary academic hospitals.
Patients and Methods All patients completed the disease-specific GIQLI and the generic SF-36 before and 3 months after
surgery. Scores using these instruments were interpreted by generalized estimating equation before and after
cholecystectomy. The bootstrap estimation was used to derive 95% confidence intervals for differences in the
responsiveness estimates.
Results and Discussion Mean changes in all GIQLI and the SF-36 subscales were statistically significant (p<0.05).
Comparisons of effect size (ES), standardized response means (SRM), and relative efficiency (>1) indicated that the
responsiveness of the GIQLI was superior to that of the SF-36. In the equivalence test, all lower or upper confidence limits
presented no equivalence (>5), indicating good MCID. The ES and SRM for emotions and physical function in the GIQLI
significantly differed from those of the SF-36 (p<0.05).
Conclusion The data in this study indicate that clinicians and health researchers should weight disease-specific measures
more heavily than generic measures when evaluating treatment outcomes.

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