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標題Title: Risk of developing sudden sensorineural hearing loss in patients with nasopharyngeal carcinoma: A population-based cohort study
作者Authors: 林永松
上傳單位Department: 通識教育中心
上傳時間Date: 2015-6-26
上傳者Author: 林永松
審核單位Department: 通識教育中心
審核老師Teacher: 林永松
檔案類型Categories: 論文Thesis
關鍵詞Keyword: nasopharyngeal carcinoma, sudden sensorineural, hearing loss, radiotherapy
摘要Abstract: Background. The purpose of this study was to explore the
risk of developing of sudden sensorineural hearing loss (SSHL) in
patients with nasopharyngeal carcinoma (NPC).
Methods. A population-based, retrospective cohort study using the
Taiwan National Health Insurance Research Database was conducted.
From 2001 to 2006, 9121 patients with newly diagnosed NPC and
45,605 comparison subjects without NPC were selected. The incidence
of SSHL at the end of 2009 was determined.
Results. The incidence of SSHL was 6.53-fold higher in the NPC group
compared to the non-NPC group (p < .001). Using Cox proportionalhazard regressions, the risk of developing SSHL increased with an
adjusted hazard ratio (HR) of 6.747 (95% confidence interval [CI] ¼
5.366–8.484) in patients with NPC compared with patients
without NPC.
Conclusion. NPC was significantly associated with an increased risk of
developing SSHL. The risk of developing SSHL increased over follow-up
time. VC 2013 Wiley Periodicals, Inc. Head Neck 36: 203–208, 2014

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