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標題Title: Risk of second primary malignancies after nasopharyngeal carcinoma: A population-based cohort study in Taiwan
作者Authors: 林永松
上傳單位Department: 通識教育中心
上傳時間Date: 2015-6-26
上傳者Author: 林永松
審核單位Department: 通識教育中心
審核老師Teacher: 林永松
檔案類型Categories: 論文Thesis
關鍵詞Keyword: nasopharyngeal carcinoma, second primary, malignancy, cancer survival, oropharyngeal carcinoma, oral cancer
摘要Abstract: ABSTRACT: Background. The purpose of this study was to examine the
risk of second primary malignancy (SPM) after nasopharyngeal
carcinoma (NPC).
Methods. We compared the incidence of SPM in patients diagnosed
with NPC at the end of 2009 using the data extracted from the
Taiwan Longitudinal Health Insurance Database between 2001 and
2008 (n ¼ 10,299), with age-matched controls (1:10; n ¼
102,990).
Results. We found a 55% increased risk of SPM in patients diagnosed
with NPC, compared to the risk of first malignancy in the age-matched
controls (incidence rate ratio [IRR] ¼ 1.55; p < .0001). Although the
diagnosis of SPM was negatively correlated with the survival of patients
with NPC (p ¼ .0011), primary NPC did not display any synergic effect
on the survival of patients with SPM, compared to age-matched controls
with a newly diagnosed malignancy (p ¼ .8986).
Conclusion. NPC is associated with an increased risk of developing an
SPM.

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