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標題Title: Hypercholesterolemia Is Correlated With an Increased Risk of Idiopathic Sudden Sensorineural Hearing Loss: A Historical Prospective Cohort Study
作者Authors: 林永松
上傳單位Department: 通識教育中心
上傳時間Date: 2015-6-26
上傳者Author: 林永松
審核單位Department: 通識教育中心
審核老師Teacher: 林永松
檔案類型Categories: 論文Thesis
關鍵詞Keyword: Idiopathic sudden sensorineural hearing loss, Hypercholesterolemia, Diabetes, Hypertension, Coronary arterial, disease.
摘要Abstract: Objective: Despite the many studies on the associated risk of cardiovascular
and cerebrovascular events in patients with hypercholesterolemia
(HCh), an association between HCh and the development of idiopathic
sudden sensorineural hearing loss (ISSNHL) has been examined in only
a few case-control studies. We tested the hypothesis that HCh is a risk
factor for developing ISSNHL.
Design: Using the Taiwan Longitudinal Health Insurance Database, we
conducted a historical prospective cohort study to compare patients
diagnosed with HCh from January 1, 2001, through to December 31,
2006 (N = 73,957) with age-matched controls (N = 73,957). We followed
each patient until the end of 2009 and evaluated the incidence of ISSNHL
for a minimum of 3 years after the initial HCh diagnosis.
Results: The incidence of ISSNHL was 1.62 times higher in the HCh
cohort than in the non-HCh cohort (10.67 versus 6.61 per 10,000 person-
years). Using Cox proportional hazard regressions, the adjusted
hazard ratio was 1.60 (95% confidence interval [CI] = 1.39–1.85). An
increased risk of developing ISSNHL, with adjusted hazard ratios of 1.48
(95% CI = 1.08–2.04) and 1.69 (95% CI = 1.18–2.43), was observed
in HCh patients with newly diagnosed comorbidities of stroke or stroke
combined with coronary artery diseases, which are both expected to
reflect the severity of HCh.
Conclusions: A diagnosis of HCh may indicate an independent risk for
ISSNHL. This finding suggests that an underlying vascular mechanism contributes
to the development of ISSNHL. We suggest that physicians counsel
patients with HCh to seek medical attention if they have hearing impairments,
because they may also have an increased risk of developing ISSNHL.

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