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標題Title: Effects of Zinc Supplementation on the Survival of Patients Who Received Concomitant Chemotherapy and Radiotherapy for Advanced Nasopharyngeal Carcinoma: Follow-Up of a Double-Blind Randomized Study With Subgroup Analysis
作者Authors: 林永松
上傳單位Department: 通識教育中心
上傳時間Date: 2015-6-26
上傳者Author: 林永松
審核單位Department: 通識教育中心
審核老師Teacher: 林永松
檔案類型Categories: 論文Thesis
關鍵詞Keyword: Zinc supplement, chemotherapy, radiotherapy, nasopharygeal carcinoma
摘要Abstract: Objectives/Hypothesis: Dietary zinc has been
reported to have positive effects on treating carcinoma.
This study examined the effects of zinc supplementation
on the improved survival of patients with
advanced nasopharyngeal carcinoma receiving concomitant
chemotherapy and radiotherapy (CCRT).
Study Design: A double-blind, placebo-controlled
clinical study with subgroup analysis.
Methods: Thirty-four patients with stages III
and IV nasopharyngeal carcinoma were selected from
a double-blind, placebo-controlled clinical study. All
the patients were randomized to receive a standard
dose (75 mg/day for 2 months) of zinc supplements or
placebo, in conjunction with CCRT. The overall local
recurrence, metastasis, and disease-free survivals
were defined as the period between the time of first
treatment to the time of death, local recurrence, or
distant metastases occurred.
Results: Patients in the experimental group
exhibited a higher 5-year overall local-free and disease-
free survival rate than the patients in the
placebo group (P ¼ .044, P ¼ .007, and P ¼ .033,
respectively). However, no significant differences
were found between both patient groups for the
5-year metastases-free survival rate (P ¼ .149).Conclusions: Zinc supplementation prescribed
in conjunction with CCRT effects attenuating local tumor
recurrence and improves the overall survival of
patients with advanced nasopharyngeal carcinoma.
The failure to reduce distant metastasis survival
might have been related in part to the more advanced
disease stages in our patients.

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