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標題Title: Risk of Developing Sudden Sensorineural Hearing Loss in Diabetic Patients: A Population-Based Cohort Study
作者Authors: 林永松
上傳單位Department: 通識教育中心
上傳時間Date: 2015-6-26
上傳者Author: 林永松
審核單位Department: 通識教育中心
審核老師Teacher: 林永松
檔案類型Categories: 論文Thesis
關鍵詞Keyword: Diabetes,MicroangiopathyVSudden deafness, Sudden sensorineural hearing loss.
摘要Abstract: Objectives: To explore the risk of development of sudden sensorineural
hearing loss (SSHL) among diabetes mellitus patients.
Study Design: A retrospective cohort study.
Setting: Population-based study of Taiwan National Health
Insurance Research Database.
Patients: Approximately 26,556 newly diagnosed diabetic patients
and 26,556 comparison subjects without diabetes mellitus
were selected from claims made during 2000 to 2004.
Main Outcome Measures: The incidence of sudden sensorineural
hearing loss (SSHL) at the end of 2009 was determined.
Results: The incidence of SSHL was 1.54-fold higher in the
diabetic group compared with the nondiabetic group (1.29 versus
0.78 per 1,000 person-years), and using Cox proportional
hazard regressions, the adjusted hazard ratio (HR) was 1.592
(95% confidence interval [CI], 1.295Y1.957). The risk of developing
SSHL increased substantially to an HR of 2.060 (95%CI, 1.051Y4.037), for patients who required triple antidiabetic
medication compared with diabetic patients treated with a single
antidiabetic drug. An increased risk of developing SSHL, with
adjusted HRs of 1.574 (95% CI, 1.091Y2.271) and 2.842 (95%
CI, 1.880Y4.295), was observed in diabetic patients with newly
diagnosed comorbidities of retinopathy or retinopathy combined
with renal insufficiency, which are both expected to reflect the
severity of diabetes.
Conclusion: Diabetes mellitus was significantly associated with
an increased risk of developing SSHL. Coronary heart disease
or retinopathy comorbidities in diabetic patients seemed to be
associated with an increased risk of developing SSHL. The risk
of developing SSHL increased with the severity of diabetes.

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