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標題Title: Risk of Sudden Sensorineural Hearing Loss in Patients with Systemic Lupus Erythematosus: A Population-Based Cohort Study
作者Authors: 林永松
上傳單位Department: 通識教育中心
上傳時間Date: 2015-6-26
上傳者Author: 林永松
審核單位Department: 通識教育中心
審核老師Teacher: 林永松
檔案類型Categories: 論文Thesis
關鍵詞Keyword: Sudden deafness, Systemic lupus erythematosus, Autoimmune disease, Sudden sensorineural hearing loss
摘要Abstract: Abstract
Sudden sensorineural hearing loss (SSHL) may be a manifestation
of systemic vascular involvement in systemic lupus
erythematosus (SLE) and may have an important impact on
the health of patients with SLE. To investigate the risk of developing
SSHL in patients with SLE, we conducted a population-
based, retrospective cohort study from the Taiwan National
Health Insurance Research Database. A total of 7168
patients diagnosed with SLE and 35840 control subjects
without SLE were selected from claims made from 2001 to
2006. The incidence of SSHL was assessed and determined
at the end of 2010. The incidence of SSHL was 2.22-fold higher
in the SLE group than in the non-SLE group (6.52 vs. 2.93
per 10000 person-years), with an adjusted hazard ratio (HR)
of 2.253 (95% confidence interval, CI = 1.407–3.608) calculated
using a Cox proportional hazard regression model. Age
was an independent risk factor for SSHL, with adjusted HRs
of 2.103 for individuals aged 6 35 years compared with those
0–34 years. In the 0–34 age range, the incidence of developing
SSHL was 4.27-fold (95% CI = 2.11–8.67) higher in the SLEgroup compared with the non-SLE group. In female patients,
the incidence of developing SSHL was 2.19-fold (95% CI =
1.73–3.50) higher in the SLE group than in the non-SLE group.
Systemic lupus erythematosus was significantly associated
with an increased risk of developing SSHL. Scheduled auditory
examinations for patients with SLE to assess the presence
of chronic hearing impairment are advised to enable
the early detection of SSHL.

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