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標題Title: Sudden Sensorineural Hearing Loss is Correlated with an Increased Risk of Acute Myocardial Infarction: A Population-Based Cohort Study
作者Authors: 林永松
上傳單位Department: 通識教育中心
上傳時間Date: 2015-6-26
上傳者Author: 林永松
審核單位Department: 通識教育中心
審核老師Teacher: 林永松
檔案類型Categories: 論文Thesis
關鍵詞Keyword: Sudden hearing loss, acute myocardial infarction, sudden sensorineural hearing loss.
摘要Abstract: Objectives/Hypothesis: Previous studies have indicated that hypercholesterolemia and a high burden of cardiovascular
risk factors are associated with the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was
to test the hypothesis that SSHL is a risk factor for the development of myocardial infarction (MI).
Study Design: A retrospective cohort study.
Methods: Using the Taiwan Longitudinal Health Insurance Database, we compared patients diagnosed with SSHL
between January 1, 2001, and December 31, 2006, (N ¼ 44,830) with age-matched controls (1:1) (N ¼ 44,830). We followed
up on each patient until the end of 2009 to evaluate the incidence of MI for a minimum period of 3 years after their initial
SSHL diagnosis.
Results: We found that after adjusting for potential confounds with an adjusted hazard ratio (HR) of 1.254 (95% confidence
interval, 1.092–1.440, P < 0.05), patients with SSHL were more likely to suffer MI than the control population. When
stratified by patient age, the incidence of MI was 1.62-fold and 1.28-fold higher for SSHL-diagnosed patients aged between 50
and 64 years and those aged  65 years (P ¼ 0.0064 and P ¼ 0.0001), respectively, than in the non-SSHL group.
Conclusions: SSHL may confer an independent risk of MI. This observation may prompt the early detection and timely
treatment of patients at a high risk of MI.

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