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標題Title: DEVELOPMENT OF IN SITU GELLING ANG INJECTABLE PLURONIC-PAA LIQUID SUPPOSITORY
作者Authors: 曾昭智,林鴻儒..等
上傳單位Department: 化學工程與材料工程系
上傳時間Date: 2009-12-1
上傳者Author: 曾昭智
審核單位Department: 化學工程與材料工程系
審核老師Teacher: 林鴻儒
檔案類型Categories: 研討會報告Seminar Report
關鍵詞Keyword: IN SITU GELLING ,LIQUID SUPPOSITORY
摘要Abstract: Abstract
Conventional suppositories are solid forms which often cause discomfort during insertion. The leakage of
suppositories from the rectum also gives uncomfortable feelings to the patients. In addition, when the solid
suppositories without mucoadhesivity reach the end of the colon; the drugs can undergo the first-pass effect. To solve these problems, we developed in situ-gelling and injectable Pluronic-PAA liquid suppository, which can gel fast in physiological state and has suitable gel strength and bioadhesive force. The liquid suppositories were inserted into the rectum of rabbits without difficulty and leakage and retained in the rectum for at least 6 h and have drug release function. These results suggest that in situ-gelling and injectable liquid suppository for humans can be further developed as a more convenient and effective rectal dosage form.

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2009_12_2d40c95c.doc 2765Kb doc 527 216
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