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標題Title: Beneficial effects of magnolol in a rodent model of endotoxin shock
作者Authors: 蔡永杰,Yung-Chieh Tsai a..等
上傳單位Department: 生物科技系
上傳時間Date: 2010-6-18
上傳者Author: 蔡永杰
審核單位Department: 生物科技系
審核老師Teacher: 蔡永杰
檔案類型Categories: 論文Thesis
關鍵詞Keyword: Magnolol, Reactive oxygen species, Sepsis, TNF-α, Nitric oxide, Circulatory failure
摘要Abstract: Magnolol is a compound extracted from the Chinese medicinal herb Magnolia officinalis. It has multiple
pharmacological effects, notably as an anti-oxidant. The aim of this study was to evaluate the effects of
magnolol on sepsis induced by intravenous (i.v.) administration of lipopolysaccharide (LPS; 10 mg/kg) in
anaesthetized Wistar rats. Magnolol (4 μg/kg, i.v.) was administered at 30 min after LPS injection. Posttreatment
with magnolol significantly attenuated the deleterious haemodynamic changes (e.g., hypotension
and bradycardia) caused by LPS. Meanwhile, magnolol significantly inhibited the elevation of plasma levels
of tumor necrosis factor alpha, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and
blood urine nitrogen caused by LPS. The induction of inducible nitrous oxide (NO) synthase and the
overproduction of NO and superoxide anions by LPS were also significantly reduced by post-treatment with
magnolol. Moreover, the plasma level of the thrombin–antithrombin complex following administration of
LPS was also reduced by post-treatment with magnolol. Thus, the beneficial effects of magnolol on LPSinduced
sepsis result from its anti-inflammatory, anti-coagulatory, and anti-oxidant effects.

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