尚未登入 請由此登入
 
 
 










知識分享平台Eshare檢視資訊View
返回前一頁Back
      [檢舉]

標題Title: A novel phosphorylcholine-coated contact lens for extended wear use
作者Authors: 江沛倉
上傳單位Department: 化學工程與材料工程系
上傳時間Date: 2009-12-4
上傳者Author: 江沛倉
審核單位Department: 化學工程與材料工程系
審核老師Teacher: 林鴻儒
檔案類型Categories: 專題報告Project Report
關鍵詞Keyword: Phosphorylcholine; Silicone hydrogel; Extended wear; Contact lens; Biocompatibility
摘要Abstract: The preparation and characterisation of a new phosphorylcholine (PC)-coated silicone hydrogel contact lens for use in extended
wear is described. The Michael-type addition of amines to acrylates forms the basis of the synthesis of a novel silicone-based
macromer with hydrophilic functionality. It is demonstrated that this macromer can be combined with other silicone-based
monomers, hydrophilic monomers and crosslinker to produce a contact lenses formulation. Examples of lenses with water contents
of 33% and 46% are illustrated and their properties compared to other commercially available lenses. Materials with comparatively
low modulus (o0.3 MPa) and adequate tear strength (>2–4 MPa) with excellent elongation to break (>200%) can be obtained
using this technology. In addition to the mechanical aspects, both the oxygen and solute permeabilities of the material can be
controlled by the hydrophilic : hydrophobic monomer balance in the formulation, to obtain materials with attributes suitable for
extended wear use. The PC coating is achieved by means of an in-mould coating (IMC) technique that produces a uniform and
stable surface as determined by staining and XPS. The coating imparts both improved lens wettability (advancing contact angle of
approximately 501 with virtually no hysteresis) and lower protein adsorption relative to the uncoated lens. r 2001 Elsevier Science
Ltd. All rights reserved.

檔案名稱
FileName
檔案大小
Size
檔案格式
Format
瀏覽次數
Browses
下載次數
Downloads
2009_12_f029d58a.ppt 1410Kb ppt 691 241
文件中檔案:
 

開啟檔案Download
 
 
返回前一頁